Jouberin antibody

Target background

Target: Jouberin (AHI1) · Homo sapiens

Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development

Subcellular location: Cytoplasm, cytoskeleton, cilium basal body; Cell junction, adherens junction; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole

Tissue specificity: Highly expressed in the most primitive normal hematopoietic cells. Expressed in brain, particularly in neurons that give rise to the crossing axons of the corticospinal tract and superior cerebellar peduncles. Expressed in kidney (renal collecting duct cells) (at protein level)

Sequence length: 1196 aa · 137115 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.