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Presenilin 1 (phospho Ser357) Polyclonal Antibody

13599

Presenilin 1 (phospho Ser357) Polyclonal Antibody

Presenilin 1 (phospho Ser357) Polyclonal Antibody (catalogue number 13599) is a rabbit-derived primary antibody validated for Western blot, IHC-p, IF(paraffin section), ELISA, reactive with Human, Mouse, Rat samples. It targets Presenilin-1 (PSEN1): Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Supplied in 2 pack sizes, from 50ul at ₪893.28 to 100ul at ₪1,301.17; the final price is confirmed on your quote and the lot certificate of analysis ships with the order.

Primary AntibodyHostRabbit
Host / source
Rabbit
Reactivity
Human, Mouse, Rat
Applications
Western blot IHC-p IF(paraffin section) ELISA
UniProt ID
P49768
Gene
PSEN1
Target organism
Homo sapiens
Catalogue number
13599
Brand
LABO Scientific
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target background

Target: Presenilin-1 (PSEN1) · Homo sapiens

Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.

Subcellular location: Endoplasmic reticulum; Endoplasmic reticulum membrane; Golgi apparatus membrane; Cytoplasmic granule; Cell membrane; Cell projection, growth cone; Early endosome; Early endosome membrane; Cell project

Tissue specificity: Detected in azurophile granules in neutrophils and in platelet cytoplasmic granules (at protein level). Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes

Sequence length: 467 aa · 52668 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.